J Curr Surg

Journal of Current Surgery, ISSN 1927-1298 print, 1927-1301 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Curr Surg and Elmer Press Inc

Journal website https://jcs.elmerpub.com

Case Report

Volume 16, Number 1, June 2026, pages 16-19

Metastatic Sigmoid Adenocarcinoma at the Right Ureter

↓ Figure 1. Neoplastic aggregates in perirenal and periureteral fat with concurrent infiltration of all ureteral layers and papillary intraluminus morphology (× 200).

↓ Figure 2. Solid and cribriform neoplastic aggregates focally with comedo necrosis (× 100).

↓ Figure 3. Immunohistochemistry profiling, CDX-2 positive (× 200). CDX2: caudal-type homeobox 2.

↓ Figure 4. Immunohistochemistry profiling, SATB2 positive (× 200). SATB2: special adenine-thymine-rich sequence-binding protein 2.

↓ Figure 5. Immunohistochemistry profiling, CK20 positive (focal, × 200). CK20: cytokeratin 20.

↓ **Table 1.** Patient Timeline
Months	Findings
CT: computed tomography; FOLFOX: folinic acid, 5-fluorouracil, oxaliplatin; MRI: magnetic resonance imaging; 18F-FDG PET-CT: 18F-fluorodeoxyglucose positron emission tomography–computed tomography; FOLFIRI: folinic acid, 5-fluorouracil, irinotecan.
0	Urgent Hartmann’s sigmoidectomy, due to perforation of the underlying sigmoid colon adenocarcinoma (grade II, stage pT4aN2b), R0 resection
1	Staging: abdomen MRI and chest CT did not confirm metastatic lesions
1–6	Adjuvant chemotherapy with FOLFOX regimen
6	Follow-up abdomen MRI and chest CT, without evidence of recurrence or progression
11	Follow-up abdomen CT revealed abnormal lesion at the left ovary
11	Total hysterectomy with a bilateral salpingo-oophorectomy, which confirmed left ovary metastasis of the primary sigmoid adenocarcinoma, R0 resection
13	Examination with 18-FDG PET-CT, which showed abnormal para-aortic and iliac lymph nodes
13–19	First-line chemotherapy/immunotherapy with FOLFIRI/panitumumab regimen
19	Follow-up abdomen and chest CT, without evidence of recurrence or progression, and with radiographically complete response of the retroperitoneal lymphadenopathy
24	Follow-up abdomen and chest CT detected intraluminal lesions of the middle and lower third of the right ureter
25	Diagnostic right ureteroscopy confirmed the presence of papillary lesions totally obstructing the ureter
26	Right nephroureterectomy, with histopathological examination confirming metastatic adenocarcinoma of colon origin, R0 resection

↓ Table 1. Patient Timeline

Months

Findings

CT: computed tomography; FOLFOX: folinic acid, 5-fluorouracil, oxaliplatin; MRI: magnetic resonance imaging; 18F-FDG PET-CT: 18F-fluorodeoxyglucose positron emission tomography–computed tomography; FOLFIRI: folinic acid, 5-fluorouracil, irinotecan.

Urgent Hartmann’s sigmoidectomy, due to perforation of the underlying sigmoid colon adenocarcinoma (grade II, stage pT4aN2b), R0 resection

Staging: abdomen MRI and chest CT did not confirm metastatic lesions

1–6

Adjuvant chemotherapy with FOLFOX regimen

Follow-up abdomen MRI and chest CT, without evidence of recurrence or progression

Follow-up abdomen CT revealed abnormal lesion at the left ovary

Total hysterectomy with a bilateral salpingo-oophorectomy, which confirmed left ovary metastasis of the primary sigmoid adenocarcinoma, R0 resection

Examination with 18-FDG PET-CT, which showed abnormal para-aortic and iliac lymph nodes

13–19

First-line chemotherapy/immunotherapy with FOLFIRI/panitumumab regimen

Follow-up abdomen and chest CT, without evidence of recurrence or progression, and with radiographically complete response of the retroperitoneal lymphadenopathy

Follow-up abdomen and chest CT detected intraluminal lesions of the middle and lower third of the right ureter

Diagnostic right ureteroscopy confirmed the presence of papillary lesions totally obstructing the ureter

Right nephroureterectomy, with histopathological examination confirming metastatic adenocarcinoma of colon origin, R0 resection