| Journal of Current Surgery, ISSN 1927-1298 print, 1927-1301 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Curr Surg and Elmer Press Inc |
| Journal website https://jcs.elmerpub.com |
Review
Volume 16, Number 2, September 2026, pages 27-33
Contribution to Diagnostic Accuracy and Prognostic Significance of MicroRNAs in Thyroid Cancer
Tables
| n | Type | Frequency (%) | Implicated genes |
|---|---|---|---|
| 1 | Well differentiated | ||
| 1a | Papillary | 84–88 | BRAF V600E, RAS, NTRK |
| 2a | Follicular | 4–7 | RAS, PTEN, PAX8 |
| 3a | Oncocytic carcinoma (Hurthle cell) | 2–5 | TP53, NRAS, TERT |
| 4a | Invasive encapsulated follicular variant of papillary | 7 of all papillary | NRAS, HPAS, PAX8 |
| 2 | Poorly differentiated | 2–3 | RAS, BRAF V600E, TP53 |
| 3 | Anaplastic | 1–2 | TP53, BRAF V600E, PIK3CA, TERT |
| 4 | Medullary | 3–5 | RET |
| Bethesda category | Description | Risk of malignancy (%) | Recommended management |
|---|---|---|---|
| FNA: fine-needle aspiration; AUS/FLUS: atypia undetermined significance/follicular lesion undetermined significance; FN/SFN: follicular neoplasm/suspicious follicular neoplasm. | |||
| I | Non-diagnostic | 5–10% | Repeat FNA |
| II | Benign | 0–3% | Clinical follow-up |
| III | AUS/FLUS | 10–30% | Repeat FNA/molecular testing |
| IV | FN/SFN | 25–40% | Molecular testing/lobectomy |
| V | Suspicious for malignancy | 50–75% | Surgical intervention |
| VI | Malignant | 97–99% | Surgical intervention |